1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication

N A Nikitenko; E S Gureeva; A A Ozerov; A I Tukhvatulin; F M Izhaeva; V S Prassolov; P G Deryabin; M S Novikov; D Y Logunov

1-(4-Phenoxybenzyl) 5-Aminouracil Derivatives and Their Analogues - Novel Inhibitors of Human Adenovirus Replication

Acta Naturae. 2018 Apr-Jun;10(2):58-64.

Authors

N A Nikitenko¹, E S Gureeva², A A Ozerov², A I Tukhvatulin¹, F M Izhaeva¹, V S Prassolov³, P G Deryabin¹, M S Novikov², D Y Logunov¹

Affiliations

¹ N.F. Gamaleya Federal National Research Center for Epidemiology and Microbiology, Gamaleya Str. 18, Moscow, 123098, Russia.
² Volgograd State Medical University, Pavshih Bortsov Sq. 1,Volgograd, 400131, Russia.
³ Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, Moscow, 119991, Russia.

PMID: 30116616
PMCID: PMC6087815

Abstract

Adenovirus infections are characterized by widespread distribution. The lack of causal therapy, which is effective in treating this group of diseases, explains the need for new therapeutic drugs. Notably, anti-adenoviral activity of [4-(phenoxy)benzyl]-5-(phenylamino)-6-azauracil, 1-[4-(phenoxy)benzyl]-5-(morpholino) uracil, 1-[4-(4-chlorophenoxy)benzyl]-5-(morpholino) uracil, and 1-[4-(4-fluorophenoxy)-benzyl]-5-(morpholino) uracil was observed.

Keywords: 5-aminouracil derivatives; Human adenovirus; adenovirus replication; inhibitors of adenovirus replication.