Cloning and characterization of a canine oral papillomavirus

Am J Vet Res. 1986 May;47(5):1142-4.

Abstract

A papillomavirus, isolated from oral papillomas in young Beagles, was used to produce a live-virus vaccine. After the IM use of this vaccine, some dogs developed squamous cell carcinomas at the inoculation site. The virus was isolated from the original vaccine and was cloned into pBR322. A detailed restriction map of the viral genome was generated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA Restriction Enzymes
  • Dog Diseases / microbiology*
  • Dogs
  • Genes, Viral
  • Mouth Neoplasms / microbiology
  • Mouth Neoplasms / veterinary*
  • Papilloma / microbiology
  • Papilloma / veterinary*
  • Papillomaviridae / genetics
  • Papillomaviridae / immunology
  • Papillomaviridae / isolation & purification*
  • Viral Vaccines / administration & dosage

Substances

  • Viral Vaccines
  • DNA Restriction Enzymes