Acute Encephalitis with Atypical Presentation of Rubella in Family Cluster, India

Emerg Infect Dis. 2018 Oct;24(10):1923-1925. doi: 10.3201/eid2410.180053.

Abstract

We report 3 atypical rubella cases in a family cluster in India. The index case-patient showed only mild febrile illness, whereas the other 2 patients showed acute encephalitis and died of the disease. We confirmed rubella in the index and third cases using next-generation sequencing and IgM.

Keywords: India; acute encephalitis; atypical; meningitis/encephalitis; next-generation sequencing; rash; rubella; viruses.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antibodies, Viral / immunology
  • Biomarkers
  • Child
  • Child, Preschool
  • Encephalitis, Viral / diagnosis*
  • Encephalitis, Viral / immunology
  • Encephalitis, Viral / virology
  • Family
  • Fatal Outcome
  • Female
  • Genome, Viral
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Immunoglobulin G / immunology
  • Immunoglobulin M / immunology
  • India
  • Male
  • Phenotype*
  • RNA, Viral
  • Rubella / diagnosis*
  • Rubella / immunology
  • Rubella / virology
  • Siblings
  • Symptom Assessment

Substances

  • Antibodies, Viral
  • Biomarkers
  • Immunoglobulin G
  • Immunoglobulin M
  • RNA, Viral