Abstract
The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine.
Keywords:
H7N9; highly pathogenic; influenza; low pathogenicity; vaccine; viruses.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antigens, Viral / immunology*
-
Disease Models, Animal
-
Female
-
Ferrets
-
Humans
-
Immunization
-
Influenza A Virus, H7N9 Subtype / genetics
-
Influenza A Virus, H7N9 Subtype / immunology*
-
Influenza A Virus, H7N9 Subtype / pathogenicity
-
Influenza Vaccines / genetics
-
Influenza Vaccines / immunology*
-
Influenza, Human / immunology*
-
Influenza, Human / prevention & control*
-
Influenza, Human / virology
-
Orthomyxoviridae Infections / immunology
-
Orthomyxoviridae Infections / prevention & control
-
Orthomyxoviridae Infections / virology
-
Recombination, Genetic
-
Vaccines, Inactivated / genetics
-
Vaccines, Inactivated / immunology*
-
Virulence
Substances
-
Antigens, Viral
-
Influenza Vaccines
-
Vaccines, Inactivated