Two-Factor Authentication for Type 2 Immunity

Jennifer S Chen; Stephanie C Eisenbarth

doi:10.1016/j.immuni.2018.08.020

Two-Factor Authentication for Type 2 Immunity

Immunity. 2018 Sep 18;49(3):381-383. doi: 10.1016/j.immuni.2018.08.020.

Authors

Jennifer S Chen¹, Stephanie C Eisenbarth²

Affiliations

¹ Departments of Laboratory Medicine and Immunobiology and Section of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT, USA.
² Departments of Laboratory Medicine and Immunobiology and Section of Rheumatology, Allergy, and Clinical Immunology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: stephanie.eisenbarth@yale.edu.

PMID: 30231976
DOI: 10.1016/j.immuni.2018.08.020

Abstract

The initiation of type 2 responses is tightly regulated. In this issue of Immunity, Sokol et al. (2018) demonstrate that CCL8 is a critical signal that licenses dendritic cells to enter the lymph node parenchyma and induce Th2 differentiation after allergen exposure.

Publication types

Comment

MeSH terms

Dendritic Cells / immunology
Humans
Lymph Nodes / immunology
Receptors, CCR8
Receptors, Chemokine
Th2 Cells / cytology*

Substances

CCR8 protein, human
Receptors, CCR8
Receptors, Chemokine