Described herein is a clinical case report regarding successive treatment of a patient presenting with total infection of an aortofemoral bifurcation vascular prosthesis and a purulent fistula in the left iliac-inguinal region. The patient was subjected to removal of the infected aortofemoral bifurcation prosthesis, followed by autovenous aortofemoral bifurcation prosthetic repair. There were no pyo-haemorrhagic complications in the postoperative period. The wounds of the femurs and in the inguinal regions healed with second intention. Check-up computed tomography performed 3 months postoperatively demonstrated satisfactory patency of the autovenous graft and no retroperitoneal formations.