When and how should we cluster and cross over: methodological and ethical issues (letter 1)

Affiliations

• ¹ Departments of Anesthesia, Critical Care and Health Research Methods, Evidence, and Impact, Population Health Research Institute (PHRI), McMaster University, Hamilton, ON, Canada. jessicaspence13@gmail.com.
• ² Departments of Medicine (Cardiology and Critical Care) and Health Research Methods, Evidence, and Impact, Population Health Research Institute (PHRI), McMaster University, Hamilton, ON, Canada.
• ³ Department of Medicine (Critical Care), McMaster University, Hamilton, ON, Canada.
• ⁴ Departments of Anesthesia and Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
• ⁵ Departments of Surgery (Cardiac Surgery) and Health Research Methods, Evidence, and Impact, Population Health Research Institute (PHRI), McMaster University, Hamilton, ON, Canada.
• ⁶ Departments of Medicine (Cardiology) and Health Research Methods, Evidence, and Impact, Population Health Research Institute (PHRI), McMaster University, Hamilton, ON, Canada.
• ⁷ Department of Medicine (Cardiology), Population Health Research Institute (PHRI), McMaster University, Hamilton, ON, Canada.