Abstract
Pulmonary adenofibroma (PAF) is a rare neoplasm that may be related to solitary fibrous tumor (SFT). A subset of PAFs harbor the NAB2-STAT6 fusion that is typical of SFT, but a significant proportion do not. Their distinction is clinically important as SFTs can potentially have an aggressive clinical course, while there has been no report of a PAF behaving in a malignant fashion. We report a case of a 60-year-old male who developed a SFT and PAF in the same lung. The SFT harbored a NAB2-STAT6 fusion, while the PAF did not have any identifiable fusion. This case represents the first instance of a single patient with both of these tumors occurring simultaneously in the same lung.
Keywords:
STAT6; pulmonary adenofibroma; pulmonary fibroepithelial neoplasm; solitary fibrous tumor.
MeSH terms
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Adenofibroma / diagnostic imaging
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Adenofibroma / genetics
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Adenofibroma / pathology*
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Adenofibroma / surgery
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Biomarkers, Tumor / genetics
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Humans
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Lung / diagnostic imaging
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Lung / pathology
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Lung / surgery
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Lung Neoplasms / diagnostic imaging
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Lung Neoplasms / genetics
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Lung Neoplasms / pathology*
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Lung Neoplasms / surgery
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Male
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Middle Aged
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Neoplasms, Multiple Primary / diagnostic imaging
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Neoplasms, Multiple Primary / genetics
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Neoplasms, Multiple Primary / pathology*
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Neoplasms, Multiple Primary / surgery
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Oncogene Proteins, Fusion / genetics
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Pneumonectomy
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Repressor Proteins / genetics
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STAT6 Transcription Factor / genetics
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Solitary Fibrous Tumors / diagnostic imaging
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Solitary Fibrous Tumors / genetics
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Solitary Fibrous Tumors / pathology*
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Solitary Fibrous Tumors / surgery
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Tomography, X-Ray Computed
Substances
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Biomarkers, Tumor
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NAB2 protein, human
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Oncogene Proteins, Fusion
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Repressor Proteins
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STAT6 Transcription Factor
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STAT6 protein, human