Objective: To investigate the correlation between tumorous cellular density (TCD) and apparent diffusion coefficient (ADC) of 3.0 T magnetic resonance diffusion weighted imaging (DWI) in local advanced lung cancer. Methods: From January 2015 to December 2017, a total of 59 patients with locally advanced lung cancer confirmed by pathology in Shaoxing People's Hospital who underwent DWI by 3.0 T magnetic resonance imaging were included.The ADC and TCD values of tumor were measured. The difference and correlation between ADC value and TCD in lung cancer were analyzed. Results: Among 59 lung cancer cases who were examined with DWI, 45 cases of TCD were obtained. Statistical analysis showed that the ADC value of small cell lung cancer (SCLC) was significantly higher than that of squamous cell carcinoma (P=0.011)and adenocarcinoma (P=0.004). TCD of small cell carcinoma was significantly higher than that of squamous cell carcinoma (P=0.007) and adenocarcinoma (P<0.01). There was no statistical difference in ADC value and TCD between squamous cell carcinoma and adenocarcinoma (all P>0.05). There was negative correlation between the ADC value and TCD in lung cancer (P=0.001, r=-0.534). Conclusions: DWI is not only beneficial to distinguish SCLC from squamous cell carcinoma and adenocarcinoma, but also can indirectly reflect the tumorous cellular density.It can provide a basis for monitoring the therapeutic effect of clinical lung cancer.
目的： 探讨局部晚期肺癌肿瘤细胞密度(TCD)与3.0 T磁共振扩散加权成像(DWI)表观扩散系数(ADC)值之间的相关性。 方法： 2015年1月至2017年12月经病理确诊的绍兴市人民医院59例局部晚期肺癌患者应用3.0 T磁共振行DWI检查，其中男48例、女11例，年龄51～85岁，平均67.6岁，测量肿瘤的ADC与TCD值，比较各组织类型肺癌病灶ADC值与病理TCD间的差异及相关性。 结果： 59例肺癌DWI检查，共取得45例TCD值，经统计学分析显示，小细胞肺癌ADC值显著>鳞癌(P＝0.011)、腺癌(P＝0.004)；小细胞肺癌TCD显著>鳞癌(P＝0.007)与腺癌(P<0.01)，鳞癌与腺癌的ADC值及TCD之间差异均无统计学意义(均P>0.05)。肺癌ADC值与病理TCD之间呈负相关(P＝0.001，r＝ －0.534)。 结论： 通过DWI检查不仅有利于鉴别小细胞肺癌、鳞癌与腺癌，并能够间接地反映肿瘤细胞密度，可为临床肺癌同步放化疗疗效的监测提供依据。.
Keywords: Cell count; Lung neoplasms; Magnetic resonance imaging.