1 Department of Medicine, McMaster University, Hamilton, ON, Canada, and Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada, and Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON, Canada; General Intensive Care Unit, Hôpital Raymond Poincaré, Laboratory of Infection and Inflammation, University of Versailles -University Paris Saclay, Garches, France; Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON, Canada.