Posaconazole Administration in Hospitalized Children in the United States

Sondra Lavigne; Brian T Fisher; Darcy Ellis; Theoklis E Zaoutis; Kevin J Downes

doi:10.1093/jpids/piy119

Posaconazole Administration in Hospitalized Children in the United States

J Pediatric Infect Dis Soc. 2019 Nov 6;8(5):481-484. doi: 10.1093/jpids/piy119.

Authors

Sondra Lavigne^{1

2

3}, Brian T Fisher^{4

5

2

6}, Darcy Ellis^{1

2}, Theoklis E Zaoutis^{4

5

2

6}, Kevin J Downes^{4

2

6}

Affiliations

¹ Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
² Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Pennsylvania.
³ School of Veterinary Medicine, University of Pennsylvania, Philadelphia.
⁴ Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁵ Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁶ Division of Infectious Diseases, Children's Hospital of Philadelphia, Pennsylvania.

PMID: 30445549
DOI: 10.1093/jpids/piy119

Abstract

In this study, we evaluated posaconazole use among hospitalized children between October 2006 and September 2015 using data from the Pediatric Health Information System. A total of 878 children (in 1949 admissions) received posaconazole, and administration increased 22% per year overall and 27% per year in children aged <13 years for whom the drug was not approved.

Keywords: antifungal; epidemiology; pediatrics; transplant; triazole.

© The Author(s) 2018. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MeSH terms

Adolescent
Antifungal Agents / administration & dosage*
Child
Child, Preschool
Drug Prescriptions / statistics & numerical data*
Female
Hospitalization*
Hospitals, Pediatric
Humans
Infant
Infant, Newborn
Male
Mycoses / drug therapy
Retrospective Studies
Triazoles / administration & dosage*
United States / epidemiology

Substances

Antifungal Agents
Triazoles
posaconazole