The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy

C R H Hedin; S R Vavricka; A J Stagg; A Schoepfer; T Raine; L Puig; U Pleyer; A Navarini; A E van der Meulen-de Jong; J Maul; K Katsanos; A Kagramanova; T Greuter; Y González-Lama; F van Gaalen; P Ellul; J Burisch; D Bettenworth; M D Becker; G Bamias; F Rieder

doi:10.1093/ecco-jcc/jjy191

The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy

J Crohns Colitis. 2019 Apr 26;13(5):541-554. doi: 10.1093/ecco-jcc/jjy191.

Authors

C R H Hedin¹, S R Vavricka², A J Stagg³, A Schoepfer⁴, T Raine⁵, L Puig⁶, U Pleyer⁷, A Navarini⁸, A E van der Meulen-de Jong⁹, J Maul^{10

11}, K Katsanos¹², A Kagramanova¹³, T Greuter^{14

15}, Y González-Lama¹⁶, F van Gaalen¹⁷, P Ellul¹⁸, J Burisch^{19

20}, D Bettenworth²¹, M D Becker²², G Bamias²³, F Rieder²⁴

Affiliations

¹ Gastroenterology unit, Patient Area Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden.
² Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
³ Centre for Immunobiology, Bart's and The London Medical School, Queen Mary University of London, London, UK.
⁴ Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
⁵ Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Teaching Hospitals NHS Foundation Trust, Cambridge, UK.
⁶ Department of Dermatology, Hospital de la Santa Creu i Sant Pau. Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
⁷ University Eye Clinic, Uveitis Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁸ Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
⁹ Department of Gastroenterology, Leiden University Medical Center, Leiden, the Netherlands.
¹⁰ Gastroenterologie am Bayerischen Platz, Berlin, Germany.
¹¹ Department of Medicine (Gastroenterology, Infectious Diseases, Rheumatology), Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹² Division of Gastroenterology, Department of Internal Medicine, Medical School, University of Ioannina School of Medical Sciences, Ioannina, Greece.
¹³ IBD Department, The Loginov Moscow Clinical Scientific Centre, Moscow, Russia.
¹⁴ Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
¹⁵ Gastroenterology Research Unit, Mayo Clinic, Rochester, MN, USA.
¹⁶ IBD Unit, Gastroenterology and Hepatology Department, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain.
¹⁷ Department of Rheumatology, Leiden University Medical Center [LUMC], Leiden, Netherlands.
¹⁸ Department of Medicine, Division of Gastroenterology, Mater Dei Hospital, Msida, Malta.
¹⁹ Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
²⁰ Abdominal Center K, Medical Section, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
²¹ Department of Medicine B, Gastroenterology and Hepatology, University Hospital Münster, Münster, Germany.
²² Department of Ophthalmology, Triemli Hospital, Zurich, Switzerland & Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
²³ National and Kapodistrian University of Athens, GI Unit, 3rd Academic Department of Internal Medicine, Sotiria Hospital, Athens, Greece.
²⁴ Department of Gastroenterology, Hepatology and Nutrition; Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

PMID: 30445584
DOI: 10.1093/ecco-jcc/jjy191

Abstract

This article reports on the sixth scientific workshop of the European Crohn's and Colitis Organisation [ECCO] on the pathogenesis of extraintestinal manifestations [EIMs] in inflammatory bowel disease [IBD]. This paper has been drafted by 15 ECCO members and 6 external experts [in rheumatology, dermatology, ophthalmology, and immunology] from 10 European countries and the USA. Within the workshop, contributors formed subgroups to address specific areas. Following a comprehensive literature search, the supporting text was finalized under the leadership of the heads of the working groups before being integrated by the group consensus leaders.

Keywords: Crohn’s disease; ECCO; erythema nodosum; extra-intestinal manifestation; inflammatory bowel disease; pyoderma gangrenosum; spondyloarthritis; ulcerative colitis; uveitis.

MeSH terms

Animals
Biomarkers
Cell Adhesion Molecules / metabolism
Chemokines / metabolism
Cross Reactions
Disease Models, Animal
Ectopic Gene Expression
Eye Diseases / etiology
Humans
Immunity, Innate / immunology
Inflammatory Bowel Diseases / complications*
Inflammatory Bowel Diseases / diagnosis
Inflammatory Bowel Diseases / immunology
Inflammatory Bowel Diseases / therapy
Skin Diseases / etiology
Spondylitis, Ankylosing / etiology
T-Lymphocytes / metabolism

Substances

Biomarkers
Cell Adhesion Molecules
Chemokines