Adhesive arachnoiditis following inadvertent epidural injection of 2% chlorhexidine in 70% alcohol-partial recovery over the ensuing eight years

Anaesth Intensive Care. 2018 Nov;46(6):572-574. doi: 10.1177/0310057X1804600606.

Abstract

We report a case of serious neurologic injury due to inadvertent epidural injection of 8 ml of the antiseptic 2% chlorhexidine in 70% alcohol during a procedure aimed to relieve the pain of labour. This resulted in immediate severe back pain, progressive tetraparesis and sphincter dysfunction caused by damage to the spinal cord and nerve roots. Subacute hydrocephalus necessitated drainage, but cranial nerve and cognitive function were spared. Magnetic resonance imaging documented marked abnormality of the spinal cord and surrounding leptomeninges. In the ensuing eight years, there has been clinical and electrophysiological evidence of partial recovery, but neurologic deficit remains severe.

Keywords: adhesive arachnoiditis; antisepsis; chlorhexidine; epidural.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alcohols / administration & dosage
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / adverse effects*
  • Arachnoiditis / chemically induced*
  • Arachnoiditis / diagnostic imaging
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / adverse effects*
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Epidural
  • Magnetic Resonance Imaging
  • Medical Errors / adverse effects*
  • Pregnancy
  • Spinal Cord / diagnostic imaging
  • Spinal Cord / pathology

Substances

  • Alcohols
  • Anti-Infective Agents, Local
  • Chlorhexidine