The Aberrant Epigenetic Modifications in the Pathogenesis of Psoriasis

Ming Zhao; Qianjin Lu

doi:10.1016/j.jisp.2018.09.007

The Aberrant Epigenetic Modifications in the Pathogenesis of Psoriasis

J Investig Dermatol Symp Proc. 2018 Dec;19(2):S81-S82. doi: 10.1016/j.jisp.2018.09.007.

Authors

Ming Zhao¹, Qianjin Lu²

Affiliations

¹ Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, China.
² Department of Dermatology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, China. Electronic address: qianlu5860@gmail.com.

PMID: 30471758
DOI: 10.1016/j.jisp.2018.09.007

Abstract

Psoriasis is a chronic and recurrent inflammatory skin disease that is characterized by abnormal keratinocyte proliferation, vascular hyperplasia, and infiltration of inflammatory cells into the dermis and epidermis. It is generally accepted that the central pathogenesis of psoriasis is dysfunction of T lymphocytes, which are affected by the complex interplay between genetic and environmental factors, including trauma, infections, stress, drugs, smoking, and alcohol consumption (Nestle et al., 2009). The environmentally induced epigenetic changes, including DNA methylation, histone modification, and microRNAs, have been shown to be involved in the pathogenesis of this disease (Zhang et al., 2012).