Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis

Mohsen Heidary; Mohammad Javad Nasiri; Mehdi Mirsaeidi; Faramarz Masjedian Jazi; Saeed Khoshnood; Michel Drancourt; Davood Darban-Sarokhalil

doi:10.1002/jcp.27859

Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis

J Cell Physiol. 2019 Jul;234(7):9994-10001. doi: 10.1002/jcp.27859. Epub 2018 Dec 12.

Authors

Mohsen Heidary^{1

2}, Mohammad Javad Nasiri³, Mehdi Mirsaeidi⁴, Faramarz Masjedian Jazi¹, Saeed Khoshnood^{5

6}, Michel Drancourt⁷, Davood Darban-Sarokhalil¹

Affiliations

¹ Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
² Student Research Committee, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
³ Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Miami, Coral Gables, Florida.
⁵ Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁶ Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁷ Aix-Marseille-Univ., IRD, MEPHI, IHU Méditerranée Infection, Marseille, France.

PMID: 30548598
DOI: 10.1002/jcp.27859

Abstract

Background: Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV.

Methods: Embase, PubMed, and Web of Science were searched for relevant studies. All statistical analyses were performed by STATA version 14.

Results: From 6,627 retrieved articles, 23 were included in the final analysis. A total of 18,463 patients with HIV were included in the analysis. The frequency of MAC infection in patients with HIV was found to be 10.6% (95% confidence interval, 6.9-14.2).

Conclusion: The relatively large fractions of HIV-infected patients were coinfected with MAC, which may poses significant public health problems. Continued progress in the development of rapid diagnostic methods and preventive therapy for MAC should lead to further improvements in survival and quality of life in patients with HIV.

Keywords: AIDS; HIV; Mycobacterium avium complex; meta-analysis.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Adult
Anti-Bacterial Agents / therapeutic use
Anti-HIV Agents / therapeutic use
Coinfection*
Female
HIV Infections / diagnosis
HIV Infections / drug therapy
HIV Infections / mortality
HIV Infections / virology*
Humans
Male
Mycobacterium avium Complex / pathogenicity*
Mycobacterium avium-intracellulare Infection / diagnosis
Mycobacterium avium-intracellulare Infection / microbiology*
Mycobacterium avium-intracellulare Infection / mortality
Mycobacterium avium-intracellulare Infection / prevention & control
Risk Factors
Treatment Outcome

Substances

Anti-Bacterial Agents
Anti-HIV Agents