An analytic model of microfluidic system triggered by thermal expansion

Yan Shi; Qian Wu; Dongyang Sun; Cunfa Gao

doi:10.1007/s10544-018-0351-z

An analytic model of microfluidic system triggered by thermal expansion

Biomed Microdevices. 2019 Jan 3;21(1):4. doi: 10.1007/s10544-018-0351-z.

Authors

Yan Shi¹, Qian Wu², Dongyang Sun³, Cunfa Gao²

Affiliations

¹ State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics & Astronautics, Nanjing, 210016, China. yshi@nuaa.edu.cn.
² State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics & Astronautics, Nanjing, 210016, China.
³ College of Aerospace Engineering, Chongqing University, Chongqing, 400044, China.

PMID: 30607628
DOI: 10.1007/s10544-018-0351-z

Abstract

Microfluidics shows a great importance in fluid control in biomedicine area. Recently, a programmable soft microfluidic system for applications of pharmacology and optogenetics is reported in Cell. Based on the theory of thermal expansion, we established an analytic model to characterize the injection process of the microfluidic systems. Finite element analyses (FEA) were employed to validate this model. The comparison between the analytic model and FEA well demonstrates the practicality of the analytic model. We also make a parametric analysis of sphere radius, central angle and expandable layer thickness on the infusion volume of the system to optimize the design.

Keywords: Analytic model; Design; Microfluidic; Thermal expansion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hot Temperature*
Lab-On-A-Chip Devices*
Microfluidic Analytical Techniques*
Models, Theoretical*