FoxP3+ CXCR5+ CD4+ T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome

Abstract

We recently explored the expression of CXCR5 on T and B cells from peripheral blood of patients with primary Sjögren's syndrome (SS). Here we investigated the frequency of CD25⁺ FoxP3⁺ CD4⁺ regulatory T cells (T_regs ) among CXCR5⁺ CD4⁺ follicular cells in the same cohort of patients. We confirm that the frequency of T_regs among follicular T cells is increased in SS patients and also provide novel data showing an increased frequency of PD-1 expressing cells among CXCR5⁺ FoxP3⁺ CD4⁺ T cells.