1 Department of Medicine, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, ON, Canada, and Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON, Canada; Hôpital Raymond Poincaré, Laboratory of Infection and Inflammation, University of Versailles, Garches, France; Department of Medicine, McMaster University, Hamilton, Ontario, ON, Canada, and Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON, Canada.