The results of a meta-analysis comparing the efficacy of clomiphene versus letrozole among couples with unexplained infertility in 2014 are in contrast to those of a randomized trial in 2015. This new meta-analysis included randomized studies that were not previously included and found that the efficacy of clomiphene or letrozole in women with unexplained infertility is comparable (Canadian Task Force Classification I).
Keywords: Letrozole; clomiphene; gonadotropin; idiopathic infertility; unexplained infertility.
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