Inflammation, infection and atherosclerosis

Trends Cardiovasc Med. 2019 Nov;29(8):468-472. doi: 10.1016/j.tcm.2019.01.004. Epub 2019 Jan 28.

Abstract

Atherosclerotic cardiovascular disease is a leading cause of death in much of the world. Adoption of a healthy lifestyle and cholesterol lowering are the key measures used to prevent major complications of atherosclerosis. Recent data have identified a critical role for inflammation mediated through activation of both innate and adaptive immune pathways in the pathophysiology of atherosclerosis opening up opportunities for development of anti-inflammatory interventions that could supplement risk factor modification and lipid lowering as an approach to further reducing the burden of atherosclerotic cardiovascular disease.

Keywords: Atherosclerosis; Vascular inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / therapeutic use
  • Anti-Inflammatory Agents / therapeutic use
  • Atherosclerosis / diagnosis
  • Atherosclerosis / drug therapy
  • Atherosclerosis / epidemiology*
  • Atherosclerosis / immunology
  • Communicable Diseases / diagnosis
  • Communicable Diseases / drug therapy
  • Communicable Diseases / epidemiology*
  • Communicable Diseases / immunology
  • Gastrointestinal Microbiome
  • Host-Pathogen Interactions
  • Humans
  • Hypolipidemic Agents / therapeutic use
  • Inflammation / diagnosis
  • Inflammation / drug therapy
  • Inflammation / epidemiology*
  • Inflammation / immunology
  • Inflammation Mediators / immunology
  • Risk Assessment
  • Risk Factors

Substances

  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Hypolipidemic Agents
  • Inflammation Mediators