Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans

Blood Adv. 2019 Mar 12;3(5):724-728. doi: 10.1182/bloodadvances.2018018895.

Anne Jan van der Meer¹, Anna Kroeze^{2

3}, Arie J Hoogendijk¹, Aicha Ait Soussan⁴, C Ellen van der Schoot⁴, Walter A Wuillemin^{5

6}, Carlijn Voermans³, Tom van der Poll^{1

7}, Sacha Zeerleder^{2

8

9

10}

¹ Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
² Department of Immunopathology.
³ Department of Hematopoiesis, and.
⁴ Department of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands.
⁵ Division of Hematology and Central Hematology Laboratory, Department of Internal Medicine, Kantonsspital Lucerne, Lucerne, Switzerland.
⁶ University of Bern, Bern, Switzerland.
⁷ Division of Infectious Diseases and.
⁸ Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands; and.
⁹ Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, and.
¹⁰ Department for BioMedical Research, University of Bern, Bern, Switzerland.

Abstract

During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells.