Endocrine Diseases and the Liver: An Update

Clin Liver Dis. 2019 May;23(2):233-246. doi: 10.1016/j.cld.2018.12.006. Epub 2019 Mar 8.

Abstract

The endocrine system is a complex interconnected system of organs that control corporeal processes and function. Primary endocrine organs are involved in hormonal production and secretion but rely on a bevy of signals from the hypothalamic-pituitary axis and secondary endocrine organs, such as the liver. In turn, proper hepatic function is maintained through hormonal signaling. Thus, the endocrine system and liver are codependent, and diseases affecting either organs can lead to alterations in function within their counterparts. This article explores the hepato-endocrine relationship, including the effects on endocrine diseases on the liver.

Keywords: Adrenal gland; Endocrine system; Estrogen; Hypothalamic-pituitary axis; Liver disease; Thyroid hormone.

Publication types

  • Review

MeSH terms

  • Adrenal Gland Diseases / complications*
  • Endocrine System Diseases / complications*
  • Endocrine System Diseases / physiopathology
  • Gonadal Steroid Hormones / physiology*
  • Humans
  • Hyperthyroidism / physiopathology
  • Hypothalamo-Hypophyseal System
  • Hypothyroidism / physiopathology
  • Liver / physiopathology*
  • Liver Diseases / etiology*
  • Liver Diseases / physiopathology
  • Pineal Gland

Substances

  • Gonadal Steroid Hormones