Abstract
Maintenance therapy with PARP inhibitors has heralded a new era in the management of recurrent epithelial ovarian cancer. The greatest effect is seen in women with BRCA1/2 tumors but those without this mutation also benefit. However, in most patients, the drugs eventually fail to prevent progression, so alternative strategies are needed. The SOLO1 trial randomized women with BRCA1/2-mutated advanced ovarian cancer to olaparib or placebo maintenance after first-line chemotherapy. Olaparib significantly improved progression-free survival to a degree that has not been seen in other first-line trials in ovarian cancer. This landmark trial is likely to change practice for this group of women. Here, we focus on the SOLO1 results in the context of the current management of advanced ovarian cancer.
Keywords:
mutation; PARP inhibitor; SOLO1; olaparib; ovarian cancer.
MeSH terms
-
Antineoplastic Agents / administration & dosage
-
Antineoplastic Agents / adverse effects
-
Antineoplastic Agents / therapeutic use*
-
Biomarkers, Tumor
-
Clinical Trials, Phase III as Topic
-
Female
-
Genes, BRCA1
-
Genes, BRCA2
-
Humans
-
Maintenance Chemotherapy
-
Molecular Targeted Therapy
-
Multicenter Studies as Topic
-
Mutation
-
Neoplasm Staging
-
Ovarian Neoplasms / diagnosis
-
Ovarian Neoplasms / drug therapy*
-
Ovarian Neoplasms / genetics
-
Ovarian Neoplasms / mortality
-
Phthalazines / administration & dosage
-
Phthalazines / adverse effects
-
Phthalazines / therapeutic use*
-
Piperazines / administration & dosage
-
Piperazines / adverse effects
-
Piperazines / therapeutic use*
-
Poly(ADP-ribose) Polymerase Inhibitors / administration & dosage
-
Poly(ADP-ribose) Polymerase Inhibitors / adverse effects
-
Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use*
-
Randomized Controlled Trials as Topic
-
Standard of Care
-
Treatment Outcome
Substances
-
Antineoplastic Agents
-
Biomarkers, Tumor
-
Phthalazines
-
Piperazines
-
Poly(ADP-ribose) Polymerase Inhibitors
-
olaparib