Cysteine and hydrophobic residues in CDR3 serve as distinct T-cell self-reactivity indices

Affiliations

• ¹ Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia. Electronic address: stephen.daley@monash.edu.
• ² Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, Australia.
• ³ Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
• ⁴ Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia.
• ⁵ Division of Hematology-Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass.
• ⁶ Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
• ⁷ Division of Pediatric Immunology and Allergy, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
• ⁸ Immunology Service, Edmond and Lily Safra Children's Hospital Sheba Medical Center, Tel Hashomer, Israel.
• ⁹ Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Md.
• ¹⁰ Department of Molecular and Translational Medicine, Pathology Unit, University of Brescia, Brescia, Italy.
• ¹¹ San Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
• ¹² San Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Milan Unit, Milan, Italy.
• ¹³ Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: luigi.notarangelo2@nih.gov.