The aim of present study was to investigate the nutritional status of patients with cronic heart failure and find correlation with disease outcomes. Initially 86 patients with different stages of CHF and 10 healthy persons were included in our study. Exclusion criteria were myocardial infarction or other concomitant acute diseases, renal failure (creatinine >250 µmol/L) in past 3 months. All patients underwent ECG, echocardiographic evaluation, clinical examination, as well as plasma samples were collected for further analysis. MPO level (ng/ml) was measured by ELISA method, hs-CRP (mg/L) was measured by turbidimetric immunoassay. The serum albumin level (g/L) was used as an indicator of protein reserves. The serum total cholesterol level (mg/dL) was used as a parameter of caloric depletion. For both tests colorimetric method were used. Statistical analyses were performed using IBM SPSS Statistics 16.0. After 6 month follow up we investigate CHF outcome (mortality). The data were collected by telephone follow up from patients or members of family. Collection of information had been became possible in 68 (79%) of cases. We found that MPO correlates with HF severity. 10 mortality cases were indentified, from which 8 patient died from cardiovasvular (CV) cause, all of them were males. In cardiovascular mortality group, the markers of inflammation (MPO, hs-CRP) were elevated significantly while markers of protein-energetical malnutrition were decreased (total protein, albumin, Total Colesterol, LDL-Cholesterol, HDL-Cholesterol). In our study malnutrition and inflammation are important predictors for assessment of disease prognoses in CHF patients. Additional management is necessary for these patients as well as further researches for elaboration of new treatment strategies.