Glial regulation of synaptic function in models of addiction

David Stellwagen; Gina M Kemp; Simone Valade; Julien Chambon

doi:10.1016/j.conb.2019.02.010

Glial regulation of synaptic function in models of addiction

Curr Opin Neurobiol. 2019 Aug:57:179-185. doi: 10.1016/j.conb.2019.02.010. Epub 2019 Jun 1.

Authors

David Stellwagen¹, Gina M Kemp², Simone Valade², Julien Chambon²

Affiliations

¹ Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada. Electronic address: david.stellwagen@mcgill.ca.
² Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

PMID: 31163290
DOI: 10.1016/j.conb.2019.02.010

Abstract

The glial regulation of synaptic function provides important modulation of the synaptic and behavioral changes induced by drugs of abuse. In some cases, this regulation is adaptive, reducing drug-induced change, and in other cases maladaptive, contributing to the induction or maintenance of these changes. Understanding the contribution of glia to addictive behaviors will be important to fully understand the development of addiction, and a critical entry into methods to potentially mitigate this affliction. This review will cover recent advances in elucidating the contribution of the major types of glia - microglia and astrocytes - to drug-induced synaptic plasticity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Astrocytes
Behavior, Addictive*
Microglia
Neuroglia*
Neuronal Plasticity

Grants and funding

CIHR/Canada