Tyrosine kinase inhibitor-induced carotid stenosis: A case report

Jeanne Hersant; Martine Gardembas; Georges Leftheriotis; Patrick Vandeputte; Pierre Abraham; Samir Henni

doi:10.1016/j.lrr.2019.100171

Tyrosine kinase inhibitor-induced carotid stenosis: A case report

Leuk Res Rep. 2019 May 25:12:100171. doi: 10.1016/j.lrr.2019.100171. eCollection 2019.

Authors

Jeanne Hersant^{1

2}, Martine Gardembas³, Georges Leftheriotis^{4

5}, Patrick Vandeputte¹, Pierre Abraham^{6

7}, Samir Henni^{1

7}

Affiliations

¹ Department of Vascular Medicine, University Hospital, Angers, France.
² Department of Vascular Surgery, University Hospital, Angers, France.
³ Department of Hematology, University Hospital, Angers, France.
⁴ Physiology and Vascular Medicine, University Hospital Pasteur 1, Nice, France.
⁵ LP2M-UMR CNRS, Nice, France.
⁶ Department of Sports Medicine, University Hospital, Angers, France.
⁷ UMR Mitovasc CNRS6015-INSERM 1083, University of Angers, France.

Abstract

Tyrosine kinase inhibitors are considered as highly effective and relatively safe drugs for the treatment of chronic myeloid leukemia. If several side effects on short and long term are well known and described, their involvement in the development of carotid stenosis remains unclear. Here, we describe a case of carotid stenosis in a patient receiving tyrosine kinase inhibitors and discuss the current literature.

Keywords: Carotid stenosis; Case report; Chronic myeloid leukemia; Tyrosine kinase inhibitor.

Publication types

Case Reports