Takotsubo syndrome: an overview of pathophysiology, diagnosis and treatment with emphasis on cancer patients

Heart Fail Rev. 2019 Nov;24(6):833-846. doi: 10.1007/s10741-019-09813-1.

Abstract

Takotsubo syndrome is a disease of great clinical importance that remains underdiagnosed. It is a form of acute heart failure characterized by a transient wall motion abnormality of the left ventricular apex typically triggered by emotional or physical stress. Takotsubo syndrome is commonly associated with cancer and results in poor outcomes. Therefore, early recognition and prompt therapy are essential to improve prognosis. The aim of this manuscript is to review the consequences of the association between cancer and Takotsubo to summarize the available evidence to guide physicians to improve the management of these patients.

Keywords: Cancer; Heart failure; Takotsubo syndrome.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Early Diagnosis
  • Female
  • Heart Failure / diagnosis
  • Heart Failure / mortality
  • Heart Failure / physiopathology
  • Heart Ventricles / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / complications*
  • Neoplasms / epidemiology
  • Prevalence
  • Prognosis
  • Stress, Psychological / complications
  • Stress, Psychological / epidemiology
  • Stroke Volume / physiology
  • Takotsubo Cardiomyopathy / diagnosis*
  • Takotsubo Cardiomyopathy / mortality
  • Takotsubo Cardiomyopathy / physiopathology*
  • Takotsubo Cardiomyopathy / therapy
  • Ventricular Remodeling / physiology
  • Young Adult