Effect of Concomitant Antibiotic and Vaccine Administration on Serologic Responses to Rotavirus Vaccine

J Pediatric Infect Dis Soc. 2020 Sep 17;9(4):479-482. doi: 10.1093/jpids/piz044.

Abstract

Data from 1174 infants enrolled in a previous rotavirus vaccine study were analyzed to determine the effect of antibiotic exposure (from 14 days before to 7 days after vaccination) on rotavirus serum immunoglobulin A (IgA) responses. Serum IgA responses 1 month after the completion of vaccination were similar among antibiotic-exposed and nonexposed infants.

Keywords: antibiotic; microbiome; pediatric; rotavirus; serology.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Anti-Bacterial Agents / administration & dosage*
  • Child
  • Female
  • Humans
  • Immunoglobulin A / blood*
  • Male
  • Rotavirus Infections / immunology
  • Rotavirus Infections / prevention & control*
  • Rotavirus Infections / virology
  • Rotavirus Vaccines / administration & dosage*
  • Rotavirus Vaccines / immunology

Substances

  • Anti-Bacterial Agents
  • Immunoglobulin A
  • Rotavirus Vaccines