The Impact of HIV-1 Drug Escape on the Global Treatment Landscape

D A Collier; C Monit; R K Gupta

doi:10.1016/j.chom.2019.06.010

The Impact of HIV-1 Drug Escape on the Global Treatment Landscape

Cell Host Microbe. 2019 Jul 10;26(1):48-60. doi: 10.1016/j.chom.2019.06.010.

Authors

D A Collier¹, C Monit¹, R K Gupta²

Affiliations

¹ Division of Infection and Immunity, University College London, London, UK.
² Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address: rkg20@ucl.ac.uk.

PMID: 31295424
DOI: 10.1016/j.chom.2019.06.010

Abstract

The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in combating the HIV epidemic and compromise the 90-90-90 target proposed by United Nations Programme on HIV/AIDS (UNAIDS) to have achieved virological suppression in 90% of all persons receiving antiretroviral therapy (ART) by the year 2020. HIVDR has implications for the persistence of HIV, the selection of current and future ART drug regimens, and strategies of vaccine and cure development. Focusing on drug classes that are in clinical use, this Review critically summarizes what is known about the mechanisms the virus utilizes to escape drug control. Armed with this knowledge, strategies to limit the expansion of HIVDR are proposed.

Keywords: HIV; antiretroviral; drug; mechanism; resistance.

Publication types

Review

MeSH terms

Anti-HIV Agents / pharmacology*
Anti-HIV Agents / therapeutic use*
Antiretroviral Therapy, Highly Active / methods*
Drug Resistance, Viral*
HIV Infections / drug therapy*
HIV Infections / epidemiology
HIV Infections / virology*
HIV-1 / drug effects*
Humans
Prevalence

Substances

Anti-HIV Agents