Metabolically healthy status and BMI in relation to depression: A systematic review of observational studies

Hanieh Malmir; Atieh Mirzababaei; Sajjad Moradi; Shahabeddin Rezaei; Khadijeh Mirzaei; Alireza Dadfarma

doi:10.1016/j.dsx.2019.01.027

Metabolically healthy status and BMI in relation to depression: A systematic review of observational studies

Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1099-1103. doi: 10.1016/j.dsx.2019.01.027. Epub 2019 Jan 22.

Authors

Hanieh Malmir¹, Atieh Mirzababaei², Sajjad Moradi³, Shahabeddin Rezaei¹, Khadijeh Mirzaei⁴, Alireza Dadfarma¹

Affiliations

¹ Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
² Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Student`s Scientific Research Center, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: ati_babaee@yahoo.com.
³ Halal Research Center of IRI, FDA, Tehran, Iran.
⁴ Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: mirzaei_kh@tums.ac.ir.

PMID: 31336451
DOI: 10.1016/j.dsx.2019.01.027

Abstract

Aim: Findings of association between metabolically healthy status and BMI and risk of depression are controversial. This study aimed to assess the relation between metabolically healthy status and BMI and depression.

Methods: All published studies up to 25 June 2018 were searched by using the databases of PubMed, ISI Web of Science, SCOPUS and Google Scholar and following key words were used: metabolically AND (healthy OR unhealthy OR benign) AND (overweight OR obes* OR "over weight") AND phenotype AND (depression OR depress* OR "depressive disorder").

Results: After screening title and abstract and considering inclusion criteria, 5 studies were found to be included in our study. Metabolically unhealthy obesity was associated with 30%-83% increased risk of depression and metabolically unhealthy non-obesity was associated with 19%-60% increased risk of depression. Metabolically healthy obesity was not associated with the risk of depression in all studies.

Conclusions: In conclusion, metabolically health status and BMI are associated with risk of depression. Metabolically unhealthy situation increased risk of depression greater than metabolically healthy status.

Keywords: Depression; Health; Metabolic syndrome; Obesity; Systematic review.

Publication types

Systematic Review

MeSH terms

Body Mass Index*
Depressive Disorder / etiology*
Health Status*
Humans
Obesity / complications*
Obesity, Metabolically Benign / complications*
Observational Studies as Topic
Overweight / complications*
Risk Factors