Abstract
Controlled Human Infection Models (CHIMs) now exist for several infectious diseases. CHIMs offer significant insight into disease pathogenesis, as well the potential to rapidly test clinical proof-of-concept of vaccine candidates. The application of CHIMs to identify a correlate of protection that may reduce the sample size of, or obviate the need for clinical efficacy studies to achieve licensure is of considerable interest to vaccine developers and public health stakeholders. This topic was the subject of a workshop at the 2018 Vaccines Against Shigella and ETEC (VASE) conference, in the context of O-antigen-based Shigella vaccines.
Keywords:
Challenge; Development; Policy; Shigella; Vaccine.
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antigens, Bacterial / chemistry
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Antigens, Bacterial / immunology
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Child
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Clinical Trials as Topic
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Congresses as Topic
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Diarrhea / epidemiology
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Diarrhea / immunology
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Diarrhea / microbiology
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Diarrhea / prevention & control*
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Dysentery, Bacillary / epidemiology
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Dysentery, Bacillary / immunology
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Dysentery, Bacillary / microbiology
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Dysentery, Bacillary / prevention & control*
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Host-Pathogen Interactions / immunology
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Humans
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Immunization / methods
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Immunogenicity, Vaccine
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Licensure / ethics
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Licensure / legislation & jurisprudence
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Models, Immunological*
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Shigella / drug effects
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Shigella / immunology*
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Shigella / pathogenicity
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Shigella Vaccines / administration & dosage
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Shigella Vaccines / biosynthesis*
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Vaccines, Conjugate
Substances
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Antigens, Bacterial
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Shigella Vaccines
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Vaccines, Conjugate