Ketogenic diet and olanzapine treatment alone and in combination reduce a pharmacologically-induced prepulse inhibition deficit in female mice

Ann-Katrin Kraeuter; Nadia Archambault; Maarten van den Buuse; Zoltán Sarnyai

doi:10.1016/j.schres.2019.08.002

Ketogenic diet and olanzapine treatment alone and in combination reduce a pharmacologically-induced prepulse inhibition deficit in female mice

Schizophr Res. 2019 Oct:212:221-224. doi: 10.1016/j.schres.2019.08.002. Epub 2019 Aug 9.

Authors

Ann-Katrin Kraeuter¹, Nadia Archambault¹, Maarten van den Buuse², Zoltán Sarnyai³

Affiliations

¹ Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, Australia; College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
² College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia; School of Psychology and Public Health, LaTrobe University, Bundoora, Melbourne, Australia; Department of Pharmacology, University of Melbourne, Australia.
³ Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, Australia; College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia. Electronic address: zoltan.sarnyai@jcu.edu.au.

PMID: 31405622
DOI: 10.1016/j.schres.2019.08.002

Abstract

We used the acute NMDA receptor hypoactivity model of schizophrenia in mice to compare the efficacy of a long-term ketogenic diet and a commonly used antipsychotic, olanzapine, and to explore the interaction between these treatments. We found that a ketogenic diet in female mice was as effective as olanzapine to diminish MK-801-induced disruption of prepulse inhibition (PPI). Furthermore, combination of the diet with olanzapine treatment resulted in a similar effect compared to either treatment alone. These results suggest that ketogenic diet can be used effectively together with antipsychotics drugs over an extended period.

Keywords: Ketogenic diet; MK-801; NMDA receptors; Olanzapine; Prepulse inhibition; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Combined Modality Therapy
Diet, Ketogenic / adverse effects*
Disease Models, Animal
Dizocilpine Maleate / pharmacology
Female
Long-Term Care
Mice
Mice, Inbred C57BL
Olanzapine / toxicity*
Prepulse Inhibition / drug effects*
Receptors, N-Methyl-D-Aspartate / drug effects
Schizophrenia / therapy
Schizophrenic Psychology
Sex Factors

Substances

Receptors, N-Methyl-D-Aspartate
Dizocilpine Maleate
Olanzapine