Relative cross reactivity of habanin, lepromin and tuberculin in guinea pigs sensitized with homologous and heterologous mycobacteria

N B Singh; A Srivastava; H P Gupta; A Kumar; V K Chaturvedi

Relative cross reactivity of habanin, lepromin and tuberculin in guinea pigs sensitized with homologous and heterologous mycobacteria

Indian J Lepr. 1988 Jul;60(3):407-12.

Authors

N B Singh¹, A Srivastava, H P Gupta, A Kumar, V K Chaturvedi

Affiliation

¹ Division of Microbiology, Central Drug Research Institute, Lucknow, India.

PMID: 3143770

Abstract

An atypical strain Mycobacterium habana has been studied for its antigenic cross reactivity with delayed type of hypersensitivity responses in guinea pigs. Guinea pigs sensitized with M. habana, M. leprae and M. tuberculosis when challenged with habanin, lepromin and tuberculin in criss-cross fashion have demonstrated strong cross reactivity with each other. Possibilities of developing M. habana as a vaccine against tuberculosis and/or leprosy has been discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Bacterial / immunology*
Cross Reactions*
Guinea Pigs
Hypersensitivity, Delayed / immunology*
Lepromin / immunology*
Mycobacterium / immunology*
Mycobacterium leprae / immunology
Mycobacterium tuberculosis / immunology
Nontuberculous Mycobacteria / classification
Nontuberculous Mycobacteria / immunology
Skin Tests
Tuberculin / immunology*
Vaccines, Attenuated / immunology

Substances

Antigens, Bacterial
Tuberculin
Vaccines, Attenuated
habanin
Lepromin