Why Is IFN-λ Less Inflammatory? One IRF Decides

Rebecca L Casazza; Helen M Lazear

doi:10.1016/j.immuni.2019.08.019

Why Is IFN-λ Less Inflammatory? One IRF Decides

Immunity. 2019 Sep 17;51(3):415-417. doi: 10.1016/j.immuni.2019.08.019.

Authors

Rebecca L Casazza¹, Helen M Lazear²

Affiliations

¹ Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
² Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: helen.lazear@med.unc.edu.

PMID: 31533051
DOI: 10.1016/j.immuni.2019.08.019

Abstract

Type I and type III interferons (IFNs) activate similar antiviral transcriptional programs, but the type I IFN response is more inflammatory. In this issue of Immunity, Forero et al. find that selective induction of the transcription factor IRF1 promotes proinflammatory chemokine expression downstream of type I IFN signaling.

Publication types

Comment

MeSH terms

Antiviral Agents*
Gene Expression Regulation
Interferon Lambda
Interferons*
Signal Transduction

Substances

Antiviral Agents
Interferons
Interferon Lambda