Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial

Amit N Vora; John H Alexander; Daniel M Wojdyla; Ronald Aronson; Christopher B Granger; Harald Darius; Stephan Windecker; Roxana Mehran; Oleg Averkov; Andrzej Budaj; David F Kong; Zhanna Kobalava; Rajendra H Mehta; Zulfiqar Mirza; Patricia Oliveira Guimaraes; Alexander Parkhomenko; Alexandre Quadros; Holger Thiele; Shaun G Goodman; Renato D Lopes

doi:10.1161/CIRCULATIONAHA.119.043754

Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial

Circulation. 2019 Dec 3;140(23):1960-1963. doi: 10.1161/CIRCULATIONAHA.119.043754. Epub 2019 Sep 25.

Authors

Amit N Vora^{1

2}, John H Alexander², Daniel M Wojdyla², Ronald Aronson³, Christopher B Granger², Harald Darius⁴, Stephan Windecker⁵, Roxana Mehran⁶, Oleg Averkov⁷, Andrzej Budaj⁸, David F Kong², Zhanna Kobalava⁹, Rajendra H Mehta², Zulfiqar Mirza¹⁰, Patricia Oliveira Guimaraes¹¹, Alexander Parkhomenko¹², Alexandre Quadros¹³, Holger Thiele¹⁴, Shaun G Goodman^{15

16}, Renato D Lopes²

Affiliations

¹ UPMC Pinnacle, Harrisburg, PA (A.N.V.).
² Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.N.V., J.H.A., D.M.W., C.B.G., D.F.K., R.H.M., R.D.L.).
³ Bristol-Myers Squibb, Lawrenceville, NJ (R.A.).
⁴ Vivantes Neukoelln Medical Center, Berlin, Germany (H.D.).
⁵ Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (S.W.).
⁶ Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, and Cardiovascular Research Foundation, New York (R.M.).
⁷ Pirogov Russian National Research Medical University, Moscow (O.A.).
⁸ Department of Cardiology, Grochowski Hospital, Warsaw, Poland (A.B.).
⁹ RUDN University, Moscow, Russia (Z.K.).
¹⁰ Witham Specialist Center, Lebanon, IN (Z.M.).
¹¹ Instituto do Coração-HCFMUSP, São Paulo, Brazil (P.O.G.).
¹² Emergency Cardiology Department, Institute of Cardiology, Kiev, Ukraine (A.P.).
¹³ Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, Brazil (A.Q.).
¹⁴ Heart Center Leipzig at University of Leipzig, Germany (H.T.).
¹⁵ Canadian VIGOUR Center, University of Alberta, Edmonton (S.G.G.).
¹⁶ Terrence Donnelly Heart Centre, St. Michael's Hospital, University of Toronto, ON, Canada (S.G.G.).

PMID: 31553201
DOI: 10.1161/CIRCULATIONAHA.119.043754

No abstract available

Keywords: acute coronary syndrome; anticoagulants; atrial fibrillation; hospitalization; percutaneous coronary intervention; platelet aggregation inhibitors.

Publication types

Comparative Study
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acute Coronary Syndrome / complications
Acute Coronary Syndrome / drug therapy*
Acute Coronary Syndrome / surgery
Aged
Anticoagulants / adverse effects
Anticoagulants / therapeutic use*
Aspirin / therapeutic use*
Atrial Fibrillation / complications
Atrial Fibrillation / drug therapy*
Cardiovascular Agents / therapeutic use*
Combined Modality Therapy
Drug Therapy, Combination
Elective Surgical Procedures
Female
Fibrinolytic Agents / adverse effects
Fibrinolytic Agents / therapeutic use*
Hemorrhage / chemically induced
Hemorrhage / epidemiology
Hospitalization / statistics & numerical data*
Humans
Length of Stay / statistics & numerical data
Male
Middle Aged
Multicenter Studies as Topic / statistics & numerical data
Percutaneous Coronary Intervention*
Platelet Aggregation Inhibitors / adverse effects
Platelet Aggregation Inhibitors / therapeutic use*
Proportional Hazards Models
Prospective Studies
Purinergic P2Y Receptor Antagonists / adverse effects
Purinergic P2Y Receptor Antagonists / therapeutic use
Pyrazoles / therapeutic use*
Pyridones / therapeutic use*
Randomized Controlled Trials as Topic / statistics & numerical data
Survival Analysis
Treatment Outcome
Vitamin K / antagonists & inhibitors

Substances

Anticoagulants
Cardiovascular Agents
Fibrinolytic Agents
Platelet Aggregation Inhibitors
Purinergic P2Y Receptor Antagonists
Pyrazoles
Pyridones
Vitamin K
apixaban
Aspirin