Successful Treatment of Amiodarone-induced Thyrotoxicosis Type 1 in Combination with Methimazole and Potassium Iodide in a Patient with Hashimoto's Thyroiditis

Intern Med. 2020 Feb 1;59(3):383-388. doi: 10.2169/internalmedicine.2179-18. Epub 2019 Sep 26.

Abstract

A patient with underlying Hashimoto's thyroiditis developed amiodarone-induced thyrotoxicosis type 1 that was successfully treated using methimazole in combination with potassium iodide. A 35-year-old woman admitted for perinatal care of twin-to-twin transfusion syndrome was given amiodarone for 7 days for paroxysmal ventricular contraction following pulseless ventricular tachycardia 1 day after delivery. She developed thyrotoxicosis one month after the discontinuation of amiodarone therapy and was negative for thyroid-stimulating hormone receptor antibody. An increased peak velocity of the superior thyroid artery suggested amiodarone-induced thyrotoxicosis type 1. Her thyroid function recovered after combination therapy with methimazole and potassium iodide.

Keywords: amiodarone; amiodarone-induced thyrotoxicosis; color flow Doppler sonography; methimazole; potassium iodide.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amiodarone / adverse effects*
  • Amiodarone / therapeutic use
  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / therapeutic use
  • Antithyroid Agents / adverse effects*
  • Antithyroid Agents / therapeutic use
  • Female
  • Hashimoto Disease / drug therapy*
  • Humans
  • Methimazole / adverse effects*
  • Methimazole / therapeutic use
  • Potassium Iodide / adverse effects*
  • Potassium Iodide / therapeutic use
  • Thyrotoxicosis / chemically induced*
  • Treatment Outcome

Substances

  • Anti-Arrhythmia Agents
  • Antithyroid Agents
  • Potassium Iodide
  • Methimazole
  • Amiodarone