Abstract
Of 27 neonates with herpes simplex virus, DNAemia was observed in 100% with disseminated disease, 57% with central nervous system disease and 28% with skin, eye, mouth disease, suggesting DNAemia occurs frequently in these infants. Herpes simplex virus culture and polymerase chain reaction were performed on surface specimens from 13/27 infants, and ~50% tested positive only by polymerase chain reaction, suggesting the superiority of this technique.
MeSH terms
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Anal Canal / virology
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Conjunctiva / virology
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DNA, Viral / blood*
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DNA, Viral / cerebrospinal fluid
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Electronic Health Records
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Female
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Herpes Simplex / blood*
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Herpes Simplex / cerebrospinal fluid
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Herpes Simplex / diagnosis*
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Humans
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Infant
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Infant, Newborn
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Male
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Mouth / virology
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Nasopharynx / virology
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Polymerase Chain Reaction*
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Pregnancy Complications, Infectious / blood*
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Pregnancy Complications, Infectious / cerebrospinal fluid
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Pregnancy Complications, Infectious / diagnosis*
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Retrospective Studies
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Simplexvirus / isolation & purification
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Tertiary Care Centers
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Viral Load
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Virus Cultivation