Crowds and power - coordinated in vitro development of a benign breast lesion

Stefan Florian; Timothy J Mitchison

doi:10.1080/23723556.2019.1648739

Crowds and power - coordinated in vitro development of a benign breast lesion

Mol Cell Oncol. 2019 Aug 26;6(6):e1648739. doi: 10.1080/23723556.2019.1648739. eCollection 2019.

Authors

Stefan Florian^{1

2}, Timothy J Mitchison²

Affiliations

¹ Institute of Pathology, Charité University Hospital, Berlin, Germany.
² Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

Abstract

We have discovered an organoid culture approach that recapitulates morphology and coordinated development of a benign breast tumor. This system may be useful to groups investigating normal mammary gland biology and coordination of collective cell behavior in the mammary gland.

Keywords: Collective cell behavior; mammary gland; organoids; spheroids; usual ductal hyperplasia.

Abstract

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