Abstract
FR65814, a novel immunosuppressant, was isolated from the cultured broth of Penicillium jensenii F-2883. The structure was assigned to be 5,6-dihydroxy-4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-1-oxaspiro++ +[2,5]octane by spectroscopic analyses. The compound suppressed the immune response at low concentration. In addition, a structually related component fumagillol, a known carcinolytic agent, was also isolated and found to show immunosuppressive activity.
MeSH terms
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Animals
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Cyclohexanes
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Fermentation
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Immunosuppressive Agents / classification
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Immunosuppressive Agents / isolation & purification*
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Immunosuppressive Agents / pharmacology
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Lymphocyte Activation / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Penicillium / analysis*
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Sesquiterpenes / classification
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / physiology
Substances
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Cyclohexanes
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Immunosuppressive Agents
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Sesquiterpenes
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FR 65814
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fumagillol