Effects of Anti-Cytokine Antibodies on Gut Barrier Function

Fang Liu; Seul A Lee; Stephen M Riordan; Li Zhang; Lixin Zhu

doi:10.1155/2019/7028253

Effects of Anti-Cytokine Antibodies on Gut Barrier Function

Mediators Inflamm. 2019 Nov 12:2019:7028253. doi: 10.1155/2019/7028253. eCollection 2019.

Authors

Fang Liu^{1

2}, Seul A Lee², Stephen M Riordan³, Li Zhang², Lixin Zhu¹

Affiliations

¹ Department of General Surgery and Central Lab, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
² School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
³ Gastrointestinal and Liver Unit, Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia.

Abstract

Anti-cytokine antibodies are used in treating chronic inflammatory diseases and autoimmune diseases such as inflammatory bowel disease and rheumatic diseases. Patients with these diseases often have a compromised gut barrier function, suggesting that anti-cytokine antibodies may contribute to the re-establishment of gut barrier integrity, in addition to their immunomodulatory effects. This paper reviews the effects of anti-cytokine antibodies on gut barrier function and their mechanisms.

Publication types

Review

MeSH terms

Animals
Antibodies / therapeutic use*
Cytokines / antagonists & inhibitors*
Cytokines / immunology*
Humans
Inflammatory Bowel Diseases / drug therapy
Inflammatory Bowel Diseases / immunology
Rheumatic Diseases / drug therapy
Rheumatic Diseases / immunology

Substances

Antibodies
Cytokines