Body-Weight Fluctuation Was Associated With Increased Risk for Cardiovascular Disease, All-Cause and Cardiovascular Mortality: A Systematic Review and Meta-Analysis

Huajie Zou; Ping Yin; Liegang Liu; Wenhua Liu; Zeqing Zhang; Yan Yang; Wenjun Li; Qunchuan Zong; Xuefeng Yu

doi:10.3389/fendo.2019.00728

Body-Weight Fluctuation Was Associated With Increased Risk for Cardiovascular Disease, All-Cause and Cardiovascular Mortality: A Systematic Review and Meta-Analysis

Front Endocrinol (Lausanne). 2019 Nov 8:10:728. doi: 10.3389/fendo.2019.00728. eCollection 2019.

Authors

Huajie Zou¹, Ping Yin², Liegang Liu^{3

4}, Wenhua Liu⁵, Zeqing Zhang¹, Yan Yang¹, Wenjun Li⁶, Qunchuan Zong⁷, Xuefeng Yu¹

Affiliations

¹ Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Hubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁴ Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Wuhan, China.
⁵ Medical Translation Center, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
⁶ Computer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁷ Department of Orthopedics, The Affiliated Hospital of Qinghai University, Medical College of Qinghai University, Xining, China.

Abstract

Background: The aim of this study was to evaluate associations between body-weight fluctuation and risk of mortality and cardiovascular diseases (CVD). Methods: PubMed, EMBASE databases and Cochrane Library were searched for cohort studies published up to May 20, 2019, reporting on associations of body-weight fluctuation and mortality from all causes, CVD and cancer, as well as morbidity of CVD and hypertension. Summary relative risks (RRs) were estimated using a random-effects model. Results: Twenty-five eligible publications from 23 studies with 441,199 participants were included. Body-weight fluctuation was associated with increased risk for all-cause mortality (RR, 1.41; 95% confidence interval (CI): 1.27-1.57), CVD mortality (RR, 1.36; 95% CI 1.22-1.52), and morbidity of CVD (RR, 1.49, 95% CI 1.26-1.76) and hypertension (RR, 1.35, 95% CI 1.14-1.61). However, there was no significant association between weight fluctuation and cancer mortality (RR, 1.01; 95% CI 0.90-1.13). No evidence of publication bias was observed (all P > 0.05) except for studies on all-cause mortality (Egger's test, P = 0.001; Begg's test, P = 0.014). Conclusions: Body-weight fluctuation was associated with higher mortality due to all causes and CVD and a higher morbidity of CVD and hypertension.

Keywords: CVD; body-weight fluctuation; meta-analysis; mortality; weight cycling.

Publication types

Systematic Review