Homeostasis disrupted by strain mechanosensing

Tyler J DiStefano; Svenja Illien-Jünger; James C Iatridis

doi:10.1038/s41551-019-0491-3

Homeostasis disrupted by strain mechanosensing

Nat Biomed Eng. 2019 Dec;3(12):951-952. doi: 10.1038/s41551-019-0491-3.

Authors

Tyler J DiStefano¹, Svenja Illien-Jünger², James C Iatridis³

Affiliations

¹ Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Emory University School of Medicine, Atlanta, GA, USA.
³ Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. james.iatridis@mssm.edu.

Abstract

In injured intervertebral discs, disruptions in fibre organization and in cellular contractility result in a fibrotic phenotype and progressive tissue degeneration.

MeSH terms

Animals
Annulus Fibrosus
Homeostasis*
Humans
Intervertebral Disc / injuries
Intervertebral Disc / pathology
Intervertebral Disc / physiology*
Joints / injuries
Joints / pathology
Joints / physiology*
Mechanotransduction, Cellular / physiology*
Models, Animal
Phenotype
Rabbits
Stress, Mechanical

Grants and funding

R01 AR057397/AR/NIAMS NIH HHS/United States