Progress and development of platelet antibody detection

L Porcelijn; E Huiskes; M de Haas

doi:10.1016/j.transci.2019.102705

Progress and development of platelet antibody detection

Transfus Apher Sci. 2020 Feb;59(1):102705. doi: 10.1016/j.transci.2019.102705. Epub 2019 Dec 31.

Authors

L Porcelijn¹, E Huiskes², M de Haas³

Affiliations

¹ Department of Immunohematology Diagnostics, Sanquin, Amsterdam, the Netherlands. Electronic address: l.porcelijn@sanquin.nl.
² Department of Immunohematology Diagnostics, Sanquin, Amsterdam, the Netherlands.
³ Department of Immunohematology Diagnostics, Sanquin, Amsterdam, the Netherlands; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands; Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands.

PMID: 31911048
DOI: 10.1016/j.transci.2019.102705

Abstract

Human platelet antibody (HPA) detection is necessary for the diagnosis and therapeutic decisions for refractoriness to platelet transfusions, post transfusion purpura and fetal and neonatal alloimmune thrombocytopenia. In the last four to five decades many new developments, both in knowledge and methods, have increased the quality of platelet serology. However, the quest for the optimal antibody detection method(s) encountered, sometimes unexpected, difficulties. In this review the various aspects concerning platelet antibody test methods and detection of platelet antibodies both for the diagnostic and screening setting are discussed.

Keywords: Antibodies; Beads; FNAIT; Human Platelet Antigens (HPA); MACE; MAIPA; Methods; Platelet antibody detection; Platelets; Screening.

Publication types

Review

MeSH terms

Blood Platelets / immunology*
Humans
Isoantibodies / blood*

Substances

Isoantibodies