Study on the Red Blood Cell Distribution Width in Connective Tissue Disease Associated with Interstitial Lung Disease

Abstract

Background: Connective tissue disease (CTD) associated with interstitial lung disease (ILD) affects the lungs and can lead to considerable morbidity and shortened survival. Red blood cell distribution width (RDW) is a readily available parameter that is routinely reported with complete blood cell count (CBC) This study aimed to investigate the predictive value of RDW in CTD-ILD.

Methods: A retrospective analysis was performed on 180 patients with CTD-ILD and 202 patients with CTD but without ILD between April 2016 and December 2018. Baseline demographics, laboratory results, imaging examinations, and results of ultrasound scans were analysed.

Results: In comparison with patients without ILD, patients with CTD-ILD displayed a larger RDW (14.65 ± 2.08 vs. 14.17 ± 1.63, P=0.002), and RDW shared positive relationships with pulmonary artery systolic pressure (r = 0.349; P=0.002), and RDW shared positive relationships with pulmonary artery systolic pressure (r = 0.349; P=0.002), and RDW shared positive relationships with pulmonary artery systolic pressure (r = 0.349; P=0.002), and RDW shared positive relationships with pulmonary artery systolic pressure (P=0.002), and RDW shared positive relationships with pulmonary artery systolic pressure (P=0.002), and RDW shared positive relationships with pulmonary artery systolic pressure (P=0.002), and RDW shared positive relationships with pulmonary artery systolic pressure (.

Conclusions: RDW was significantly increased in patients with CTD-ILD under various CTD backgrounds and may be a promising biomarker that may help physicians predict CTD-ILD risk.