Infections after kidney transplantation: A comparison of mTOR-Is and CNIs as basic immunosuppressants. A systematic review and meta-analysis

Transpl Infect Dis. 2020 Jun;22(3):e13267. doi: 10.1111/tid.13267. Epub 2020 Mar 6.

Abstract

Background: Side effects of the immunosuppressive therapy after solid organ transplantation are well known. Recently, significant benefits were shown for mTOR-Is with respect to certain viral infections in comparison with CNIs. However, reported total incidences of infections under mTOR-Is vs CNIs are usually not different. This raises the question to additional differences between these immunosuppressants regarding development and incidence of infections.

Methods: The current literature was searched for prospective randomized controlled trials in renal transplantation. There were 954 trials screened of which 19 could be included (9861 pts.). The 1-year incidence of infections, patient and graft survival were assessed in meta-analyses.

Results: Meta-analysis on 1-year incidence of infections showed a significant benefit of an mTOR-I based therapy when combined with a CNI vs CNI-based therapy alone (OR 0.76). There was no difference between mTOR-I w/o CNI and CNI therapy (OR 0.97). For pneumonia, a significant disadvantage was seen only for mTOR-I monotherapy compared to CNI's (OR 2.09). The incidence of CMV infections was significantly reduced under mTOR-I therapy (combination with CNI: OR 0.30; mTOR w/o CNI: OR: 0.46). There was no significant difference between mTOR-I and CNI therapy with respect to patient survival (mTOR-I w/o CNI vs CNI: OR 1.22; mTOR-I with CNI vs CNI: OR 0.86). Graft survival was negatively affected by mTOR-I monotherapy (OR 1.52) but not when combined with a CNI (OR 0.97).

Conclusion: Following renal transplantation the incidence of infections is lower when mTOR-Is are combined with a CNI compared to a standard CNI therapy. Pneumonia occurs more often under mTOR-I w/o CNI.

Keywords: calcineurin inhibitor; infection; mTOR inhibitor; renal transplantation.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Calcineurin Inhibitors / therapeutic use*
  • Humans
  • Immunosuppressive Agents / classification
  • Immunosuppressive Agents / therapeutic use*
  • Infections / drug therapy
  • Infections / epidemiology*
  • Kidney Transplantation / adverse effects*
  • Randomized Controlled Trials as Topic
  • TOR Serine-Threonine Kinases / therapeutic use*

Substances

  • Calcineurin Inhibitors
  • Immunosuppressive Agents
  • MTOR protein, human
  • TOR Serine-Threonine Kinases

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