The immunopathogenesis of tuberculous pericarditis

Microbes Infect. 2020 May-Jun;22(4-5):172-181. doi: 10.1016/j.micinf.2020.02.001. Epub 2020 Feb 21.

Abstract

Tuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8 and 34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in the histology, microbiology and immunology of tuberculous pericarditis, with special focus on the effect of Human Immunodeficiency Virus (HIV) and the determinants of constriction.

Keywords: Constriction; HIV; Immunology; Pathogenesis; Pericardial; Tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / immunology*
  • AIDS-Related Opportunistic Infections / microbiology
  • AIDS-Related Opportunistic Infections / pathology*
  • AIDS-Related Opportunistic Infections / therapy
  • Humans
  • Models, Immunological
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / pathogenicity
  • Pericardial Effusion / immunology
  • Pericardial Effusion / therapy
  • Pericarditis, Constrictive / immunology
  • Pericarditis, Constrictive / therapy
  • Pericarditis, Tuberculous / immunology*
  • Pericarditis, Tuberculous / microbiology
  • Pericarditis, Tuberculous / pathology*
  • Pericarditis, Tuberculous / therapy
  • T-Lymphocytes / immunology