Acquired Factor XIII Deficiency Inducing Recurrent and Fatal Bleeding, Description of a Case

Pierpaolo Di Micco; Gualberto Gussoni; Filippo Pieralli; Mauro Campanini; Francesco Dentali; Andrea Fontanella

doi:10.2147/JBM.S232115

Acquired Factor XIII Deficiency Inducing Recurrent and Fatal Bleeding, Description of a Case

J Blood Med. 2020 Jan 30:11:43-45. doi: 10.2147/JBM.S232115. eCollection 2020.

Authors

Pierpaolo Di Micco¹, Gualberto Gussoni², Filippo Pieralli³, Mauro Campanini⁴, Francesco Dentali⁵, Andrea Fontanella¹

Affiliations

¹ Department of Internal Medicine and Emergency Room, Fatebenefratelli Hospital of Naples, Naples, Italy.
² Centro Studi FADOI, Milan, Italy.
³ Department of Medicine, Hospital Careggi, Florence, Italy.
⁴ Department of Internal Medicine, Ospedale Maggiore, Novara, Italy.
⁵ Department of Internal Medicine, University of Insubria, Varese, Italy.

Abstract

Factor XIII deficiency may be inherited or acquired. Inherited deficiency is associated with signs and symptoms of minor bleeding from a young age, and possible major bleeding complications, in particular during pregnancy. On the other hand, acquired factor XIII deficiency is usually associated with severe symptoms of major bleeding, in particular during surgery. In this paper, we report an interesting case of recurrent major bleeding with subsequent fatal bleeding in an adult man diagnosed with acquired factor XIII deficiency.

Keywords: acquired haemophilia; bleeding; blood disorders; factor XIII deficiency; fatal bleeding.

Publication types

Case Reports