[White matter hyperintensities in ageing: Pathophysiology, associated cognitive disorders and prevention]

Abstract

White matter hyperintensities (WMH), also known as leukoaraïosis are very common neuroradiological manifestations in the elderly. The main risk factors for WMH are age and high blood pressure. The vascular origin of these lesions is classically accepted and WMH are considered as one feature of the small vessel disease. WMH may be associated with clinical symptoms, depending notably on their importance according to age. They are associated with increased mortality, strokes and changes in cognition with a higher risk of dementia (vascular dementia or Alzheimer's disease). Modification of vascular risk factors could have a beneficial effect, but few evidences from controlled trials are available.

Keywords: Brain aging; Cognitive disorders; Hypersignaux de la substance blanche; Leucoaraïose; Leukoaraïosis; Troubles cognitifs; Vieillissement cérébral; White matter hyperintensities.