PD-1: A Driver or Passenger of T Cell Exhaustion?

Xing He; Chenqi Xu

doi:10.1016/j.molcel.2020.02.013

PD-1: A Driver or Passenger of T Cell Exhaustion?

Mol Cell. 2020 Mar 5;77(5):930-931. doi: 10.1016/j.molcel.2020.02.013.

Authors

Xing He¹, Chenqi Xu²

Affiliations

¹ State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
² State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China. Electronic address: cqxu@sibcb.ac.cn.

PMID: 32142689
DOI: 10.1016/j.molcel.2020.02.013

Abstract

Okazaki and colleagues report that PD-1 signaling mainly restrains effector function at the early stage of T cell activation. The authors find that cytokine genes require strong antigen stimulation and are more susceptible to PD-1 inhibition.

Publication types

Comment

MeSH terms

Lymphocyte Activation
Programmed Cell Death 1 Receptor / genetics*
Signal Transduction
T-Lymphocytes / immunology*
Transcriptome

Substances

Programmed Cell Death 1 Receptor